Dr Nick Fuller
Leading Obesity Expert at the University of Sydney and founder of Interval Weight Loss.
Weight loss injections, like semaglutide or other GLP-1 medications, have become a popular tool for shedding kilos effectively. But once you’ve hit your goal, a common question pops up: can you stop weight loss injections? The short answer is yes—but it requires planning, patience, and a strategy to maintain your results. Research shows that abrupt discontinuation without lifestyle support can lead to weight regain (JAMA, 2023). In this guide, we’ll break down when it’s safe to stop, what changes to expect, and how to keep your hard-earned weight off for the long term.
When to Stop Weight Loss Injections
Deciding when to discontinue your injections isn’t just about reaching a number on the scale. Several key indicators suggest you might be ready:
If your weight has plateaued at a healthy target for several months, it may be time to discuss tapering your injections. Studies indicate that maintenance phases are critical for preventing rebound weight gain after medication-assisted weight loss (Diabetes, Obesity and Metabolism, 2022).
When you naturally choose balanced meals, control portion sizes, and limit highly processed foods without relying on medication, your body is adjusting to new routines that can sustain weight independently.
Weight loss injections work primarily by reducing appetite and promoting satiety. If you notice your hunger signals are steady and cravings are under control without relying on the drug, you might be ready to wean off.
Never stop injections abruptly without medical oversight. Your provider can help develop a tapering schedule and monitor for weight changes, nutrient deficiencies, or blood sugar fluctuations.
A positive, mindful approach to eating—where food is fuel rather than stress relief—is an essential part of sustaining results. Stopping medication without mental readiness increases the risk of relapse.
What to Expect When Stopping Weight Loss Injections
Even with planning, your body will respond to the absence of medication. Understanding these changes can help you stay on track:
Research shows appetite-regulating hormones like ghrelin rise after discontinuing GLP-1 medications, making you feel hungrier (Obesity Reviews, 2021).
You might notice previously controlled portion sizes feel smaller or less satisfying, requiring conscious effort to maintain appropriate servings.
It’s normal to see slight weight gains in the weeks following cessation. The key is that these fluctuations are generally minor if lifestyle habits are solid.
Food may regain its emotional pull, triggering stress or reward eating patterns. Mindful eating and journaling can help manage this phase.
Without the “automatic” appetite suppression, structured meals and regular physical activity become essential for maintaining results.
What Actually Happens When You Lose Weight Loss Injections
Stopping injections doesn’t just reverse weight loss; it triggers several physiological changes:
Appetite signals increase – hunger hormones rise and satiety cues are reduced.
Fullness cues change – you may not feel satisfied after meals as quickly as before.
Cravings may return – especially for high-sugar or high-fat foods.
Portion control requires more awareness – you’ll need to measure or track food more closely.
Hormone levels begin to rebalance – insulin sensitivity and leptin levels shift over time.
Weight maintenance becomes more active – lifestyle choices now play a bigger role than before.
Emotional relationship with food shifts – building resilience against emotional or habitual eating is key.
In What Cases Do People Gain Weight After Stopping Weight Loss Injections
Even with the best intentions, some people regain weight after stopping injections. Common pitfalls include:
Stopping suddenly without a plan – abrupt cessation can trigger rapid hunger and overeating.
Returning to previous eating patterns – indulgent habits that were controlled by medication can cause rebound weight gain.
Lack of protein and fiber intake – these nutrients help maintain satiety and stable blood sugar.
High stress and poor sleep – both are strongly linked to weight regain and appetite dysregulation (Frontiers in Nutrition, 2020).
No long-term lifestyle changes – weight maintenance requires sustainable habits, not just short-term fixes.
The Right Way to Stop Weight Loss Injections
The goal is to transition safely while maintaining results:
Gradual tapering is recommended – slowly reducing the dose under medical supervision minimises appetite spikes.
Maintaining structured meals – prioritise balanced meals with protein, fibre, and healthy fats to stay full.
Prioritising strength training and movement – exercise preserves muscle mass and boosts metabolism, helping prevent weight regain.
Monitoring hunger and weight trends – keep a log to identify patterns early and adjust accordingly.
Ongoing medical or nutrition support – regular check-ins with a clinician or dietitian help sustain results and provide accountability.
Conclusion
Yes, you can stop weight loss injections after reaching your goal, but it requires planning, awareness, and a shift to sustainable lifestyle habits. By tapering carefully, maintaining structured nutrition, and supporting your mental and emotional relationship with food, you can preserve your results long term. Remember, the injections were a tool—but the real work for lasting weight maintenance comes from building habits that last a lifetime.
Dr Nick Fuller is the founder of Interval Weight Loss and is a leading obesity expert at the University of Sydney with a Ph.D. in Obesity Treatment. Dr Fuller is also the author of three best-selling books and his work been published in top ranked journals in the medical field, including JAMA, Lancet and American Journal of Clinical Nutrition.